Julius Caesar could have stayed home on March 15, 44 B.C. But mocking the soothsayer who had predicted his death, the emperor rode in his litter to Rome’s Forum. There he met the iron daggers of 60 senators.

As he lay in a pool of blood, he may have gasped a final incrimination to his protégé Brutus: You too, my son? Or maybe not. But he certainly would have breathed a dying breath, a final exhalation of some 25 sextillion gas molecules. And it’s entirely possible that you just breathed in one of them.
In fact, calculating the probability of a particle of Caesar’s dying breath appearing in any given liter of air (the volume of a deep breath) has become a classic exercise for chemistry and physics students. If you make a few assumptions about the mixing of gases and the lifetimes of molecules in the atmosphere, it turns out that, on average, one molecule of “Caesar air” — or any other historic liter of air, for that matter — appears in each breath you take.

Author Sam Kean begins his book Caesar’s Last Breath with this exercise, noting that “we can’t escape the air of those around us.” It’s all recycled, and every day we breathe in a bit of our, and Earth’s, history. “The story of Earth,” he writes, “is the story of its gases.”

Kean, author of a best seller about the periodic table, The Disappearing Spoon, then tells that story. As he did in his fascinating portraits of the elements, Kean profiles individual gases such as nitrogen and oxygen primarily through the scientists and entrepreneurs who discovered or sought to harness them. These are quirky men (and they are mostly men) — every bit as obsessed, greedy and brilliant as one could hope for in a page-turner.

Along with lesser-known backstories of textbook heroes such as James Watt, Antoine-Laurent Lavoisier and Albert Einstein (who was surprisingly obsessed with building a better refrigerator), Kean clearly delights in weaving in the unexpected. In the discussion of helium, we learn about Joseph-Michel Montgolfier, the papermaker who was inspired to build the first hot-air balloon as he watched his wife’s pantaloons billowing suggestively above a fire. And in a chapter on the radioactive elements carried in nuclear fallout, there’s Pig 311, a sow that survived a nuclear test blast only to be used as propaganda for the weapons’ supposed safety.

Along the way, Kean threads in the history of Earth’s atmosphere in a surprisingly compelling narrative of geologic history. He steps aside from Lavoisier’s work on life-giving oxygen, for example, to describe the Great Oxygenation Event, which infused the atmosphere a couple billion years ago with a gas that, at the time, was toxic to most living things. The explanations of science here and throughout the book are written clearly and at a level that should be understandable with a high school education. And while they’re straightforward, the explanations have enough depth to be satisfying; by the end of the book, you realize you’ve learned quite a bit.
Even those who rarely read science will enjoy the drama — death, for instance, plays a big role in these stories. Over and over, we learn, men have taken gases’ powers too lightly, or wielded their own power too cruelly, and paid the price. Fritz Haber, for instance, could have died a hero for finding a way to make fertilizer from the nitrogen in air. Instead, he died broke and loathed for his World War I work on gas warfare.

Then there was Harry Truman — not that Truman, but the one who refused to leave his home when scientists warned of an impending volcanic eruption. Truman contended that officials were “lying like horses trot” right up until Mount St. Helens blew searing gases that erased him from the mountainside.

The links between these stories can seem at first as ephemeral as the gases, but together they tell the story of the birth of the atmosphere and humans’ history in it. In the end, like Caesar’s breath, it all comes full circle.

Books about the history of science, like many other histories, must contend with the realization that others have come before. Their tales have already been told. So such a book is worth reading, or buying, only if it offers something more than the same old stories.

In this case, The Oxford Illustrated History of Science offers most obviously an excellent set of illustrations and photographs from science’s past, from various ancient Egyptian papyruses to the Hubble Space Telescope’s ultradeep view of distant galaxies. Some of the images will be familiar to science fans; many others are obscure but apt; nearly all help illustrate various aspects of science’s history.
And yet the pictures, while many may be worth more than 10,000 words, are still just complements to the text. Oxford attempts a novel organization for recounting the story of science: a sometimes hard-to-follow mix of chronological and topical. The first section, “Seeking Origins,” has six chapters that cover ancient Mediterranean science, science in ancient China, medieval science (one chapter for the Islamic world and Europe, one for China), plus the scientific revolution and science in the Enlightenment. The second section, “Doing Science,” shifts to experimenting, fieldwork, biology, cosmology, theory and science communication.
Each chapter has a different author, which has the plus of bringing distinct expertise to each subject matter but the minus of vast divergence in readability and caliber of content. Some chapters (see “Exploring Nature,” on field science) are wordy, repetitive and lack scientific substance. Others (“Mapping the Universe”) are compelling, engaging and richly informative. A particularly disappointing chapter on biology (“The Meaning of Life”) focuses on 19th century evolution, with only a few paragraphs for the life science of the 20th and 21st centuries. That chapter closes with an odd, antiscientific tone lamenting the “huge numbers of people … addicted to antidepressants” and complaining that modern biology (and neuroscience) “threatens to undermine traditional values of moral responsibility.”

Some of the book’s strongest chapters are the earliest, especially those that cover aspects of science often missing in other histories, such as science in China. Who knew that the ancient Chinese had their own set of ancient elements — not the Greeks’ air, earth, water and fire, but rather wood, fire, water, soil and metal?

With the book’s second-half emphasis on how science was done rather than what science found out, the history that emerges is sometimes disjointed and out of order. Discussions of the modern view of the universe, which hinges on Einstein’s general theory of relativity, appear before the chapter on theory, where relativity is mentioned. In fact, both relativity and quantum theory are treated superficially in that chapter, as examples of the work of theorists rather than the components of a second scientific revolution.
No doubt lack of space prevented deeper treatment of science from the last century. Nevertheless the book’s merits outweigh its weaknesses. For an accessible account of the story of pre-20th century science, it’s informative and enjoyable. For more recent science, you can at least look at the pictures.

This year’s Atlantic hurricane season has already proven to be active and deadly. Powerful hurricanes such as Harvey, Irma and Maria are also providing a testing ground for new tools that scientists hope will save lives by improving forecasts in various ways, from narrowing a storm’s future path to capturing swift changes in the intensity of storm winds.

Some of the tools that debuted this year — such as the GOES-16 satellite — are already winning praise from scientists. Others, such as a new microsatellite system aiming to improve measurements of hurricane intensity and a highly anticipated new computer simulation that forecasts hurricane paths and intensities, are still in the calibration phase. As these tools get an unprecedented workout thanks to an unusually ferocious series of storms, scientists may know in a few months whether hurricane forecasting is about to undergo a sea change.

The National Oceanic and Atmospheric Administration’s GOES-16 satellite is perhaps the clearest success story of this hurricane season so far. Public perceptions of hurricane forecasts tend to focus on uncertainty and conflicting predictions. But in the big picture, hurricane models adeptly forecasted Irma’s ultimate path to the Florida Keys nearly a week before it arrived there, says Brian Tang, an atmospheric scientist at the University at Albany in New York.
“I found that remarkable,” he says. “Ten or so years ago that wouldn’t have been possible.”

One reason for this is GOES-16, which launched late last year and will become fully operational in November. The satellite offers images at four times the resolution of previous satellites. “It’s giving unparalleled details about the hurricanes,” Tang says, including data on wind speeds and water temperatures delivered every minute that are then fed into models.

GOES-16’s crystal-clear images also give forecasters a better picture of the winds swirling around a storm’s central eye. But more data from this crucial region is needed to improve predictions of just how strong a hurricane might get. Scientists continue to struggle to predict rapid changes in hurricane intensity, Tang says. He notes how Hurricane Harvey, for example, strengthened suddenly to become a Category 4 storm right before it made landfall in Texas, offering emergency managers little time to issue warnings. “That’s the sort of thing that keeps forecasters up at night,” he says.
In December, NASA launched a system of eight suitcase-sized microsatellites called the Cyclone Global Navigation Satellite System, or CYGNSS, into orbit. The satellites measure surface winds near the inner core of a hurricane, such as between the eyewall and the most intense bands of rain, at least a couple of times a day. Those regions have previously been invisible to satellites, measured only by hurricane-hunter airplanes darting through the storm.

“Improving forecasts of rapid intensification, like what occurred with Harvey on August 25, is exactly what CYGNSS is intended to do,” says Christopher Ruf, an atmospheric scientist at the University of Michigan in Ann Arbor and the lead scientist for CYGNSS. Results from CYGNSS measurements of both Harvey and Irma look very promising, he says. While the data are not being used to inform any forecasts this year, the measurements are now being calibrated and compared with hurricane-hunter flight data. The team will give the first detailed results from the hurricane season at the annual meeting of the American Geophysical Union in December.
Meanwhile, NOAA has also been testing a new hurricane forecast model this year. The U.S. forecasting community is still somewhat reeling from its embarrassing showing during 2012’s Hurricane Sandy, which the National Weather Service had predicted would go out to sea while a European meteorological center predicted, correctly, that it would squarely hit New York City. In the wake of that event, Congress authorized $48 million to improve U.S. weather forecasting, and in 2014 NOAA held a competition to select a new weather prediction tool to improve its forecasts.

The clear winner was an algorithm developed by Shian-Jiann Lin and colleagues at NOAA’s Geophysical Fluid Dynamics Laboratory in Princeton, N.J. In May, NOAA announced that it would test the new model this hurricane season, running it alongside the more established operational models to see how it stacks up. Known as FV3 (short for Finite-Volume Cubed-Sphere Dynamical Core), the model divides the atmosphere into a 3-D grid of boxes and simulates climate conditions within the boxes, which may be as large as 4 kilometers across or as small as 1 kilometer across. Unlike existing models, FV3 can also re-create vertical air currents that move between boxes, such as the updrafts that are a key element of hurricanes as well as tornadoes and thunderstorms.

But FV3’s performance so far this year hasn’t been a slam dunk. FV3 did a far better job at simulating the intensity of Harvey than the other two leading models, but it lagged behind the European model in determining the hurricane’s path, Lin says. As for Irma, the European model outperformed the others on both counts. Still, Lin says he is confident that FV3 is on the right track in terms of its improvement. That’s good because pressure to work out the kinks may ramp up rapidly. Although NOAA originally stated that FV3 would be operational in 2019, “I hear some hints that it could be next year,” he says.

Lin adds that a good model alone isn’t enough to get a successful forecast; the data that go into a model are ultimately crucial to its success. “In our discipline, we call that ‘garbage in, garbage out,’” he says. With GOES-16 and CYGNSS nearly online, scientists are looking forward to even better hurricane models thanks to even better data.

WASHINGTON, D.C. — Helper cells in the brain just got tagged with a new job — forming traumatic memories.

When rats experience trauma, cells in the hippocampus — an area important for learning — produce signals for inflammation, helping to create a potent memory. But most of those signals aren’t coming from the nerve cells, researchers reported November 15 at the Society for Neuroscience meeting.

Instead, more than 90 percent of a key inflammation protein comes from astrocytes. This role in memory formation adds to the repertoire of these starburst-shaped cells, once believed to be responsible for only providing food and support to more important brain cells (SN Online: 8/4/15).
The work could provide new insight into how the brain creates negative memories that contribute to post-traumatic stress disorder, said Meghan Jones, a neuroscientist at the University of North Carolina at Chapel Hill.

Jones and her colleagues gave rats a short series of foot shocks painful enough to “make you curse,” she said. A week after that harrowing experience, rats confronted with a milder shock remained jumpy. In some rats, Jones and her colleagues inhibited astrocyte activity during the original trauma, which prevented the cells from releasing the inflammation protein. Those rats kept their cool in the face of the milder shock.

These preliminary results show that neurons get a lot of help in creating painful memories. Studies like these are “changing how we think about the circuitry that’s involved in depression and post-traumatic stress disorder,” says neuroscientist Georgia Hodes of Virginia Tech in Blacksburg. “Everyone’s been focused on what neurons are doing. [This is] showing an important effect of cells we thought of as only being supportive.”

Immune reactions against proteins commonly used as molecular scissors might make CRISPR/Cas9 gene editing ineffective in people, a new study suggests.

About 79 percent of 34 blood donors tested had antibodies against the Cas9 protein from Staphylococcus aureus bacteria, Stanford University researchers report January 5 at bioRxiv.org. About 65 percent of donors had antibodies against the Cas9 protein from Streptococcus pyogenes.

Nearly half of 13 blood donors also had T cells that seek and destroy cells that make S. aureus Cas9 protein. The researchers did not detect any T cells that attack S. pyogenes Cas9, but the methods used to detect the cells may not be sensitive enough to find them, says study coauthor Kenneth Weinberg.
Cas9 is the DNA-cutting enzyme that enables researchers to make precise edits in genes. Antibodies and T cells against the protein could cause the immune system to attack cells carrying it, making gene therapy ineffective.

The immune reactions may be a technical glitch that researchers will need to work around, but probably aren’t a safety concern as long as cells are edited in lab dishes rather than in the body, says Weinberg, a stem cell biologist and immunologist.

“We think we need to address this now … as we move toward clinical trials,” he says, but “this is probably going to turn out to be more of a hiccup than a brick wall.”

THE WOODLANDS, Texas — Venus’ crust is broken up into chunks that shuffle, jostle and rotate on a global scale, researchers reported in two talks March 20 at the Lunar and Planetary Science Conference.

New maps of the rocky planet’s surface, based on images taken in the 1990s by NASA’s Magellan spacecraft, show that Venus’ low-lying plains are surrounded by a complex network of ridges and faults. Similar features on Earth correspond to tectonic plates crunching together, sometimes creating mountain ranges, or pulling apart. Even more intriguing, the edges of the Venusian plains show signs of rubbing against each other, also suggesting these blocks of crust have moved, the researchers say.
“This is a new way of looking at the surface of Venus,” says planetary geologist Paul Byrne of North Carolina State University in Raleigh.

Geologists generally thought rocky planets could have only two forms of crust: a stagnant lid as on the moon or Mars — where the whole crust is one continuous piece — or a planet with plate tectonics as on Earth, where the surface is split into giant moving blocks that sink beneath or collide with each other. Venus was thought to have one solid lid (SN: 12/3/11, p. 26).

Instead, those options may be two ends of a spectrum. “Venus may be somewhere in between,” Byrne said. “It’s not plate tectonics, but it ain’t not plate tectonics.”

While Earth’s plates move independently like icebergs, Venus’ blocks jangle together like chaotic sea ice, said planetary scientist Richard Ghail of Imperial College London in a supporting talk.
Ghail showed similar ridges and faults around two specific regions on Venus that resemble continental interiors on Earth, such as the Tarim and Sichuan basins in China. He named the two Venusian plains the Nuwa Campus and Lada Campus. (The Latin word campus translates as a field or plain, especially one bound by a fence, so he thought it was fitting.)
Crustal motion may be possible on Venus because the surface is scorching hot (SN: 3/3/18, p. 14). “Those rocks already have to be kind of gooey” from the high temperatures, Byrne said. That means it wouldn’t take a lot of force to move them. Venus’ interior is also probably still hot, like Earth’s, so convection in the mantle could help push the blocks around.

“It’s a bit of a paradigm shift,” says planetary scientist Lori Glaze of NASA’s Goddard Space Flight Center, who was not involved in the new work. “People have always wanted Venus to be active. We believe it to be active, but being able to identify these features gives us more of a sense that it is.”

The work may have implications for astronomers trying to figure out which Earth-sized planets in other solar systems are habitable (SN: 4/30/16, p. 36). Venus is almost the same size and mass as the Earth. But no known life exists on Venus, where the average surface temperature is 462° Celsius and the atmosphere is acidic. Scientists have long speculated that the planet’s apparent lack of plate tectonics might play a role in making the planet so seemingly uninhabitable.

What’s more, the work also underlines the possibility that planets go through phases of plate tectonics (SN: 6/25/16, p. 8). Venus could have had plate tectonics like Earth 1 billion or 2 billion years ago, according to a simulation presented at the meeting by geophysicist Matthew Weller of the University of Texas at Austin.

“As Venus goes, does that predict where the Earth is going in the relatively near future?” he wondered.