WASHINGTON, D.C. — Helper cells in the brain just got tagged with a new job — forming traumatic memories.

When rats experience trauma, cells in the hippocampus — an area important for learning — produce signals for inflammation, helping to create a potent memory. But most of those signals aren’t coming from the nerve cells, researchers reported November 15 at the Society for Neuroscience meeting.

Instead, more than 90 percent of a key inflammation protein comes from astrocytes. This role in memory formation adds to the repertoire of these starburst-shaped cells, once believed to be responsible for only providing food and support to more important brain cells (SN Online: 8/4/15).
The work could provide new insight into how the brain creates negative memories that contribute to post-traumatic stress disorder, said Meghan Jones, a neuroscientist at the University of North Carolina at Chapel Hill.

Jones and her colleagues gave rats a short series of foot shocks painful enough to “make you curse,” she said. A week after that harrowing experience, rats confronted with a milder shock remained jumpy. In some rats, Jones and her colleagues inhibited astrocyte activity during the original trauma, which prevented the cells from releasing the inflammation protein. Those rats kept their cool in the face of the milder shock.

These preliminary results show that neurons get a lot of help in creating painful memories. Studies like these are “changing how we think about the circuitry that’s involved in depression and post-traumatic stress disorder,” says neuroscientist Georgia Hodes of Virginia Tech in Blacksburg. “Everyone’s been focused on what neurons are doing. [This is] showing an important effect of cells we thought of as only being supportive.”

Sperm from stressed-out dads can carry that stress from one generation to another. “But one question that really hasn’t been addressed is, ‘How do dad’s experiences actually change his germ cell?’” Jennifer Chan, a neuroendocrinologist at the University of Pennsylvania, said November 13 in Washington, D.C., at the annual meeting of the Society for Neuroscience.

Now, from a study in mice, Chan and her colleagues have some answers, and even hints at ways to stop this stress inheritance.
The researchers focused on the part of the male reproductive tract called the caput epididymis, a place where sperm cells mature. Getting rid of a stress-hormone sensor there called the glucocorticoid receptor stopped the transmission of stress, the researchers found. When faced with an alarming predator odor, offspring of chronically stressed mice dads overproduce the stress hormone corticosterone. But mice dads that lacked this receptor in the epididymis had offspring with normal hormonal responses.

Earlier work has shown that epididymis cells release small packets filled with RNA that can fuse to sperm and change their genetic payload. Experiments on cells in dishes revealed that chronic exposure to corticosterone changed the RNA in these vesicles. The results offer an explanation of how stress can change sperm: By activating the glucocorticoid receptor, stress tweaks the RNA in epididymis vesicles. Then, those vesicles deliver their altered contents to sperm, passing stress to the next generation.

Similar vesicles are present in human seminal fluid, even after ejaculation. Chan and colleagues are testing whether humans carry similar signs of stress in these RNA-loaded vesicles by studying college students’ semen samples. Exam schedules will be used as a stress indicator, she said.

Immune reactions against proteins commonly used as molecular scissors might make CRISPR/Cas9 gene editing ineffective in people, a new study suggests.

About 79 percent of 34 blood donors tested had antibodies against the Cas9 protein from Staphylococcus aureus bacteria, Stanford University researchers report January 5 at bioRxiv.org. About 65 percent of donors had antibodies against the Cas9 protein from Streptococcus pyogenes.

Nearly half of 13 blood donors also had T cells that seek and destroy cells that make S. aureus Cas9 protein. The researchers did not detect any T cells that attack S. pyogenes Cas9, but the methods used to detect the cells may not be sensitive enough to find them, says study coauthor Kenneth Weinberg.
Cas9 is the DNA-cutting enzyme that enables researchers to make precise edits in genes. Antibodies and T cells against the protein could cause the immune system to attack cells carrying it, making gene therapy ineffective.

The immune reactions may be a technical glitch that researchers will need to work around, but probably aren’t a safety concern as long as cells are edited in lab dishes rather than in the body, says Weinberg, a stem cell biologist and immunologist.

“We think we need to address this now … as we move toward clinical trials,” he says, but “this is probably going to turn out to be more of a hiccup than a brick wall.”

LOS ANGELES — In the search for new superconductors, scientists are leaving no stone — and no meteorite — unturned. A team of physicists has now found the unusual materials, famous for their ability to conduct electricity without resistance, within two space rocks.

The discovery implies that small amounts of superconducting materials might be relatively common in meteorites, James Wampler of the University of California, San Diego, said March 6 at a meeting of the American Physical Society. While the superconducting materials found weren’t new to science, additional interplanetary interlopers might harbor new, more technologically appealing varieties of superconductors, the researchers suggest.
Superconductors could potentially beget new, energy-saving technologies, but they have one fatal flaw: They require very cold temperatures to function, making them impractical for most uses. So scientists are on the hunt for new types of superconductors that work at room temperature (SN: 12/26/15, p. 25). If found, such a substance could lead to dramatic improvements in power transmission, computing and high-speed magnetically levitated trains, among other things.

Space rocks are a good avenue to explore in the search for new, exotic materials, says Wampler. “Meteorites are formed under these really unique, really extreme conditions,” such as high temperatures and pressures.

What makes the meteorite superconductors special, the researchers say, is that they occurred naturally, instead of being fabricated in a lab, as most known superconductors are. In fact, says physicist Ivan Schuller, also of University of California, San Diego, these are the highest temperature naturally occurring superconductors known — although they still have to be superchilled to about 5 kelvins (–268.15° C) to work. They are also the first known to have formed extraterrestrially.

“At this point, it’s a novelty,” says chemist Robert Cava of Princeton University. Although Cava is skeptical that scrutinizing meteorites will lead to new, useful superconductors, he says, it’s “kinda cool” that superconductors show up in meteorites.
Wampler, Schuller and colleagues bombarded bits of powdered meteorite with microwaves and looked for changes in how those waves were absorbed as the temperature changed. The sensitive technique can pick out minute traces of superconducting material within a sample.

Analysis of powdered scrapings from more than a dozen meteorites showed that two meteorites contained superconducting material. However, the superconductors found within the meteorites were run-of-the-mill varieties, made from alloys of metals including indium, tin and lead, which are already known to superconduct.

“The idea is, try to look for something that is very unusual,” such as a room temperature superconductor, says Schuller, who led the research. So far, that hope hasn’t been realized — but that hasn’t deterred the search for something more exotic. For a previous study, Wampler, Schuller and colleagues scanned 65 tiny micrometeorites, but found no superconductors at all.

Since parts of space are colder than 5 kelvins, some meteorites may even contain materials that were once superconducting in their chilly natural habitat. That’s an interesting idea, Wampler says, although it’s too early to say whether that possibility might have any astronomical implications for how the objects behave out in space.

Bit by bit, Jupiter is revealing its deepest, darkest secrets.

The latest findings are in from the Juno spacecraft. And they unveil the roots of the planet’s storms, what lies beneath the opaque atmosphere and a striking geometric layout of cyclones parked around the gas giant’s north and south poles.

“We’re at the beginning of dissecting Jupiter,” says Juno mission leader Scott Bolton of the Southwest Research Institute in San Antonio. And the picture that’s emerging — still just a sketch — topples many preconceived notions. The results appear in four papers in the March 8 Nature.
Juno has been orbiting Jupiter since July 4, 2016, on a mission to map the planet’s interior (SN: 6/25/16, p. 16). The probe loops around once every 53 days, traveling on an elongated orbit that takes the spacecraft from pole to pole and as close as about 4,000 kilometers above the cloud tops.

As it plows through Jupiter’s gravity field, Juno speeds up and slows down in response to shifting masses inside the planet. By measuring these minute accelerations and decelerations, scientists can calculate subtle variations in Jupiter’s gravity and deduce how its mass is distributed. That lets researchers build up a three-dimensional map of the planet’s internal structure. At the same time, Juno snaps pictures in visible and infrared light. While other probes have extensively photographed much of the planet, Juno is the first to get an intimate look at the north and south poles.

“The whole thing is really intriguing, especially when you compare [Jupiter] to other giant planets,” says Imke de Pater, a planetary scientist at the University of California, Berkeley. “They are all unique, it looks like.”
Check out these four surprising new things we’ve learned that make Jupiter one of a kind:

1. Rings of cyclones
   Parked at each pole is a cyclone several thousand kilometers wide. That part isn’t surprising. But each of those cyclones is encircled by a polygonal arrangement of similarly sized storms — eight in the north and five in the south. The patterns have persisted throughout Juno’s visit.

“We don’t really understand why that would happen, and why they would collect up there in such a geometric fashion,” Bolton says. “That’s pretty amazing that nature is capable of something like that.”

2. More than skin deep
   Researchers have long debated whether the photogenic bands of clouds that wrap around Jupiter have deep roots or just skim the top of the atmosphere. Juno’s new look shows that the bands penetrate roughly 3,000 kilometers below the cloud tops. That’s 30 times as thick as the bulk of Earth’s atmosphere. While just a tiny fraction of Jupiter’s diameter, that’s deeper than previously thought, Bolton says.
3. Weighty weather
   Within those 3,000 kilometers lies what passes for an atmosphere on Jupiter. It’s the stage on which Jupiter’s turbulent weather plays out. The atmosphere alone is about three times as massive as our planet, or 1 percent of Jupiter’s entire mass, researchers estimate.
4. Stuck together
   Below the atmosphere, Jupiter is fluid. But unlike most fluids, the planet rotates as if it’s a solid mass. Like kids playing crack-the-whip, atoms of hydrogen and helium figuratively link arms and spin around the planet in unison, scientists report. Earlier results from Juno also indicate there’s no solid core lurking beneath this fluid (SN: 6/24/17, p. 14), so anyone dropped into the planet can expect a terribly long fall.

Many of these results are preliminary, and it’s unclear what it all means for how Jupiter operates. But what’s been learned so far, Bolton says, “is quite different than anybody anticipated.”

LOS ANGELES — In the search for new superconductors, scientists are leaving no stone — and no meteorite — unturned. A team of physicists has now found the unusual materials, famous for their ability to conduct electricity without resistance, within two space rocks.

The discovery implies that small amounts of superconducting materials might be relatively common in meteorites, James Wampler of the University of California, San Diego, said March 6 at a meeting of the American Physical Society. While the superconducting materials found weren’t new to science, additional interplanetary interlopers might harbor new, more technologically appealing varieties of superconductors, the researchers suggest.
Superconductors could potentially beget new, energy-saving technologies, but they have one fatal flaw: They require very cold temperatures to function, making them impractical for most uses. So scientists are on the hunt for new types of superconductors that work at room temperature (SN: 12/26/15, p. 25). If found, such a substance could lead to dramatic improvements in power transmission, computing and high-speed magnetically levitated trains, among other things.

Space rocks are a good avenue to explore in the search for new, exotic materials, says Wampler. “Meteorites are formed under these really unique, really extreme conditions,” such as high temperatures and pressures.

What makes the meteorite superconductors special, the researchers say, is that they occurred naturally, instead of being fabricated in a lab, as most known superconductors are. In fact, says physicist Ivan Schuller, also of University of California, San Diego, these are the highest temperature naturally occurring superconductors known — although they still have to be superchilled to about 5 kelvins (–268.15° C) to work. They are also the first known to have formed extraterrestrially.

“At this point, it’s a novelty,” says chemist Robert Cava of Princeton University. Although Cava is skeptical that scrutinizing meteorites will lead to new, useful superconductors, he says, it’s “kinda cool” that superconductors show up in meteorites.
Wampler, Schuller and colleagues bombarded bits of powdered meteorite with microwaves and looked for changes in how those waves were absorbed as the temperature changed. The sensitive technique can pick out minute traces of superconducting material within a sample.

Analysis of powdered scrapings from more than a dozen meteorites showed that two meteorites contained superconducting material. However, the superconductors found within the meteorites were run-of-the-mill varieties, made from alloys of metals including indium, tin and lead, which are already known to superconduct.

“The idea is, try to look for something that is very unusual,” such as a room temperature superconductor, says Schuller, who led the research. So far, that hope hasn’t been realized — but that hasn’t deterred the search for something more exotic. For a previous study, Wampler, Schuller and colleagues scanned 65 tiny micrometeorites, but found no superconductors at all.

Since parts of space are colder than 5 kelvins, some meteorites may even contain materials that were once superconducting in their chilly natural habitat. That’s an interesting idea, Wampler says, although it’s too early to say whether that possibility might have any astronomical implications for how the objects behave out in space.

There’s been a lot of talk about fake news running rampant online, but now there’s data to back up the discussion.

An analysis of more than 4.5 million tweets and retweets posted from 2006 to 2017 indicates that inaccurate news stories spread faster and further on the social media platform than true stories. The research also suggests that people play a bigger role in sharing falsehoods than bots.

These findings, reported in the March 9 Science, could guide strategies for curbing misinformation on social media. Until now, most investigations into the spread of fake news have been anecdotal, says Filippo Menczer, an informatics and computer scientist at Indiana University Bloomington not involved in the work. “We didn’t have a really large-scale, systematic study evaluating the spread of misinformation,” he says.
To study rumormongering trends on Twitter, researchers examined about 126,000 tweet cascades — families of tweets composed of one original tweet and all the retweets born of that original post. All of those cascades centered on one of about 2,400 news stories that had been verified or debunked by at least one fact-checking organization.
Deb Roy, a media scientist at MIT, and colleagues investigated how far and fast each cascade spread. Discussions of false stories tended to start from fewer original tweets, but some of those retweet chains then reached tens of thousands of users, while true news stories never spread to more than about 1,600 people. True news stories also took about six times as long as false ones to reach 1,500 people. Overall, fake news was about 70 percent more likely to be retweeted than real news.
Roy and colleagues initially removed the activity of automated Twitter accounts called bots from the analysis. But when bot traffic was added back into the mix, the researchers found that these computer programs spread false and true news about equally. This finding indicates that humans, rather than bots, are primarily to blame for spreading fake news on the platform.

People may be more inclined to spread tall tales because these stories are perceived to be more novel, says study coauthor Soroush Vosoughi, a data scientist at MIT. Compared to the topics of true news stories, fake news topics tended to deviate more from the tweet themes users were exposed to in the two months before a user retweeted a news story. Tweet replies to false news stories also contained more words indicating surprise.

It’s not entirely clear what kinds of conversations these stories sparked among users, as the researchers didn’t inspect the full content of all the posts in the dataset. Some people who retweeted fake news posts may have added comments to debunk those stories. But Menczer says the analysis still provides a “very good first step” in understanding what kinds of posts grab the most attention.

The study could help guide strategies for fighting the spread of fake news, says Paul Resnick, a computational social scientist at the University of Michigan in Ann Arbor who was not involved in the work. For instance, the finding that humans are more liable to retweet falsehoods than bots may mean that social media platforms should focus on discouraging humans from spreading rumors, rather than simply booting off misbehaved bots.

To help users identify true stories online, social media sites could label news pieces or media outlets with veracity scores — similar to how grocery stores and food producers offer nutrition facts, says study coauthor Sinan Aral, an expert on information diffusion in social networks at MIT. Platforms also could restrict accounts reputed to spread lies. It’s still unclear how successful such interventions might be, Aral says. “We’re barely starting to scratch the surface on the scientific evidence about false news, its consequences and its potential solutions.”

“The strangest place in the whole universe might just be right here.” So says actor Will Smith, narrating the opening moments of a new documentary series about the wonderful unlikeliness of our own planet, Earth.

One Strange Rock, premiering March 26 on the National Geographic Channel, is itself a peculiar and unlikely creation. Executive produced by Academy Award–nominated Darren Aronofsky and by Jane Root of the production company Nutopia and narrated by Smith, the sprawling, ambitious 10-episode series is chock-full of stunningly beautiful images and CGI visuals of our dynamic planet. Each episode is united by a theme relating to Earth’s history, such as the genesis of life, the magnetic and atmospheric shields that protect the planet from solar radiation and the ways in which Earth’s denizens have shaped its surface.
The first episode, “Gasp,” ponders Earth’s atmosphere and where its oxygen comes from. In one memorable sequence, the episode takes viewers on a whirlwind journey from Ethiopia’s dusty deserts to the Amazon rainforest to phytoplankton blooms in the ocean. Dust storms from Ethiopia, Smith tells us, fertilize the rainforest. And that rainforest, in turn, feeds phytoplankton. A mighty atmospheric river, fueled by water vapor from the Amazon and heat from the sun, flows across South America until it reaches the Andes and condenses into rain. That rain erodes rock and washes nutrients into the ocean, feeding blooms of phytoplankton called diatoms. One out of every two breaths that we take comes from the photosynthesis of those diatoms, Smith adds.
As always, Smith is an appealing everyman. But the true stars of the series may be the eight astronauts, including Chris Hadfield and Nicole Stott, who appear throughout the series. In stark contrast to the colorful images of the planet, the astronauts are filmed alone, their faces half in shadow against a black background as they tell stories that loosely connect to the themes. The visual contrast emphasizes the astronauts’ roles as outsiders who have a rare perspective on the blue marble.
“Having flown in space, I feel this connection to the planet,” Stott told Science News . “I was reintroduced to the planet.” Hadfield had a similar sentiment: “It’s just one tiny place, but it’s the tiny place that is ours,” he added.
Each astronaut anchors a different episode. In “Gasp,” Hadfield describes a frightening moment during a spacewalk outside the International Space Station when his eyes watered. Without gravity, the water couldn’t form into teardrops, so it effectively blinded him. To remove the water, he was forced to allow some precious air to escape his suit. It’s a tense moment that underscores the pricelessness of the thin blue line, visible from space, that marks Earth’s atmosphere. “It contains everything that’s important to us,” Hadfield says in the episode. “It contains life.”

Stott, meanwhile, figures prominently in an episode called “Storm.” Instead of a weather system, the title refers to the rain of space debris that Earth has endured throughout much of its history — including the powerful collision that formed the moon (SN: 4/15/17, p. 18). Stott describes her own sense of wonder as a child, watching astronauts land on our closest neighbor — and how the travels of those astronauts and the rocks they brought back revealed that Earth and the moon probably originated from the same place.

It’s glimpses like these into the astronauts’ lives and personalities — scenes of Hadfield strumming “Space Oddity” on a guitar, for example, or Stott chatting with her son in the family kitchen — that make the episodes more than a series of beautiful and educational IMAX films. Having been away from the planet for a short time, the astronauts see Earth as precious, and they convey their affection for it well. Stott said she hopes that this will be the ultimate takeaway for viewers, for whom the series may serve as a reintroduction to the planet they thought they knew so well. “I hope that people will … appreciate and acknowledge the significance of [this reintroduction],” she said, “that it will result in an awareness and obligation to take care of each other.”
Editor’s note: This story was updated on March 19, 2018, to add a mention of a second executive producer.

THE WOODLANDS, Texas — Venus’ crust is broken up into chunks that shuffle, jostle and rotate on a global scale, researchers reported in two talks March 20 at the Lunar and Planetary Science Conference.

New maps of the rocky planet’s surface, based on images taken in the 1990s by NASA’s Magellan spacecraft, show that Venus’ low-lying plains are surrounded by a complex network of ridges and faults. Similar features on Earth correspond to tectonic plates crunching together, sometimes creating mountain ranges, or pulling apart. Even more intriguing, the edges of the Venusian plains show signs of rubbing against each other, also suggesting these blocks of crust have moved, the researchers say.
“This is a new way of looking at the surface of Venus,” says planetary geologist Paul Byrne of North Carolina State University in Raleigh.

Geologists generally thought rocky planets could have only two forms of crust: a stagnant lid as on the moon or Mars — where the whole crust is one continuous piece — or a planet with plate tectonics as on Earth, where the surface is split into giant moving blocks that sink beneath or collide with each other. Venus was thought to have one solid lid (SN: 12/3/11, p. 26).

Instead, those options may be two ends of a spectrum. “Venus may be somewhere in between,” Byrne said. “It’s not plate tectonics, but it ain’t not plate tectonics.”

While Earth’s plates move independently like icebergs, Venus’ blocks jangle together like chaotic sea ice, said planetary scientist Richard Ghail of Imperial College London in a supporting talk.
Ghail showed similar ridges and faults around two specific regions on Venus that resemble continental interiors on Earth, such as the Tarim and Sichuan basins in China. He named the two Venusian plains the Nuwa Campus and Lada Campus. (The Latin word campus translates as a field or plain, especially one bound by a fence, so he thought it was fitting.)
Crustal motion may be possible on Venus because the surface is scorching hot (SN: 3/3/18, p. 14). “Those rocks already have to be kind of gooey” from the high temperatures, Byrne said. That means it wouldn’t take a lot of force to move them. Venus’ interior is also probably still hot, like Earth’s, so convection in the mantle could help push the blocks around.

“It’s a bit of a paradigm shift,” says planetary scientist Lori Glaze of NASA’s Goddard Space Flight Center, who was not involved in the new work. “People have always wanted Venus to be active. We believe it to be active, but being able to identify these features gives us more of a sense that it is.”

The work may have implications for astronomers trying to figure out which Earth-sized planets in other solar systems are habitable (SN: 4/30/16, p. 36). Venus is almost the same size and mass as the Earth. But no known life exists on Venus, where the average surface temperature is 462° Celsius and the atmosphere is acidic. Scientists have long speculated that the planet’s apparent lack of plate tectonics might play a role in making the planet so seemingly uninhabitable.

What’s more, the work also underlines the possibility that planets go through phases of plate tectonics (SN: 6/25/16, p. 8). Venus could have had plate tectonics like Earth 1 billion or 2 billion years ago, according to a simulation presented at the meeting by geophysicist Matthew Weller of the University of Texas at Austin.

“As Venus goes, does that predict where the Earth is going in the relatively near future?” he wondered.